No. 23 Wake Forest @ Vanderbilt 

Sept. 10, 11:00 a.m. CT, SEC Network

This season marks the first time since 2018 that Vanderbilt has started 2-0, and this Saturday could make it 3-0. However, Vanderbilt could be shaken up by Wake Forest and head coach Dave Clawson, the 2021 ACC Coach of the Year, who led them to an 11-3 record last year. A strong Vanderbilt defense will be needed against Wake Forest’s  redshirt junior running back Christian Turner and redshirt junior quarterback Sam Hartman, who returns to the field after a non-football medical issue.      

No. 9 Baylor @ No. 21 BYU 

Sept. 10, 9:15 p.m. CT, ESPN

The reigning Big 12 champion looks to face BYU this Saturday, but it might be surprising to learn that BYU is favored over Baylor by DraftKings and FanDuel. Both teams just came off blowout wins in Week 1, but BYU suffered injuries to their top two wideouts, Puka Nacua and Gunner Romney. Nacua left towards the end of first half with a sprained ankle, and Romney’s injury is still undisclosed and his status is unknown.      

No. 24 Tennessee @ No. 17 Pittsburgh

Sept. 10, 2:30 p.m. CT, ABC

Tennessee dominated Ball State on Saturday in an easy 59-10 win. Pittsburgh, on the other hand, seemed to barely make it past West Virginia in a 38-31 Backyard Brawl victory. There’s still a lot of uncertainty swirling around Pittsburgh’s program after the loss of Kenny Pickett and subsequent addition of  USC transfer Kedon Slovis.  

No. 25 Houston @ Texas Tech

Sept. 10, 3:00 p.m. CT, ESPN

The Cougars scraped together a 37-35 win after going into triple overtime against unranked UTSA, all thanks to Houston’s star quarterback Clayton Tune. Houston might have the upper hand this week, after Texas Tech lost its starting quarterback Tyler Shough to a shoulder injury during its game against Murray State. This matchup will truly be a test of whether the Red Raiders can survive without their quarterback and if the Cougars can secure another win with theirs.     

No. 20 Kentucky @ No. 12 Florida 

Sept. 10, 6:00 p.m. CT, ESPN

Though Kentucky snagged a 37-13 win over Miami (OH), many issues in their offensive line left room for error. Just last year, Kentucky brought in transfer Will Levis as quarterback in an attempt to revamp its offense. The Wildcats look to face Florida, who just defeated No. 7 Utah at home under new head coach Billy Napier and went from being unranked to No. 12 in the AP Poll rankings. Fans can expect an entertaining showdown in the Swamp to see if Florida can continue its high-flying start to the season.