No. 13 Michigan State at Michigan, Oct. 31, 11 a.m. CT, FOX

Jim Harbaugh and his khakis are hoping to keep the Paul Bunyan Trophy in Ann Arbor. The Wolverines are looking to capitalize on their win against Minnesota and Michigan State’s loss against Rutgers to assume command of the Big Ten. But if Harbaugh is to defeat his in-state rival, he needs to utilize his running back talent against Michigan State’s revamped offense.

Texas at No. 6 Oklahoma State, Oct. 31, 3 p.m. CT, FOX

After getting back on track with a win against Baylor, the Longhorns travel to Stillwater to face the No. 6 Oklahoma State Cowboys. The last time Texas made the trip to OSU, Texas head coach Tom Herman and Oklahoma State head coach Mike Gundy nearly fist fought at midfield. Will Tom Herman and Mike Gundy throw hands this year, or will emotions be tamed?

No. 3 Ohio State at No. 18 Penn State, Oct. 31, 6:30 p.m. CT, ABC

Penn State is fresh off an upset overtime loss to the Indiana Hoosiers. This weekend, the Nittany Lions play host to the No. 3 Ohio State Buckeyes. In order to pull off the upset, the Nittany Lions defense must curb Ohio State’s explosive offense and Heisman Trophy candidate quarterback Justin Fields. Ironically, Fields first committed to Penn State out of high school before decommitting to attend Georgia.

Memphis at No. 7 Cincinnati, Oct. 31, 11 a.m. CT, ESPN

In a rematch of last year’s American Athletic Conference Championship Game, the 4–0 Bearcats will continue their dark horse run into the College Football Playoff and host the Memphis Tigers. While the Bearcats come into the game with a better record, the Tigers have something to prove. Due to scheduling issues with FC Cincinnati at Nippert Stadium, UC has denied Memphis the opportunity to hold their walk-through and Victory Walk at the stadium. Will the Tigers use this snub to get the upset, or will the Bearcats continue to make their case for the College Football Playoff?

Arkansas at No. 8 Texas A&M, Oct. 31, 6:30 p.m. CT, SEC Network

While No. 8 Texas A&M enters Saturday’s game as the heavy favorite, the Aggies should expect a fight with Arkansas. Arkansas has been one of college football’s biggest surprises this season. The Razorbacks entered the season with a 20-game SEC losing streak but snapped that streak with a win against Mississippi State in Week 2. While the Razorbacks have strong momentum heading into the game, they are entering uncharted territory. Normally, this game is played at the AT&T Stadium in Arlington, Texas, but due to the COVID-19 pandemic, the game was moved to Kyle Field. The Aggies have won every matchup since joining the SEC in 2012, but maybe the Razorbacks can snap this streak as well.